Benchtop NMR
Five benchtop NMR spectrometers (2x 43 MHz, 1x 60 MHz, 2x 80 MHz) are available in the LASE MR group. The compact and easy-to-use benchtop NMR spectrometers use permanent magnetsto to keep investment and operating costs to a minimum. These instruments can be used to record 1H and 13C NMR spectra, as well as to determine diffusion coefficients. Primarily, Benchtop NMR spectrometers are used in the field of reaction and process monitoring due to their compact design.
13C benchtop NMR spectroscopy in continuous flow
1H NMR spectroscopy is mainly used in benchtop NMR spectrometers due to the prominent signal intensity for quantitative analysis, for example in the context of reaction and process tracking. However, signal overlap occurs due to the low spectral resolution in 1H NMR spectra, which is especially present in benchtop NMR spectrometers because of the low magnetic field strength. This is challenging for quantitative evaluation of complex multicomponent mixtures. The 13C NMR spectrum has greater spectral resolution, but has significantly low signal intensity. We are therefore working on polarization transfer methods that transfer the higher polarization from 1H nuclei to 13C nuclei, allowing 13C benchtop NMR spectroscopy in continuous flow.
